Author:
Wen Hongfeng,Jin Di,Cai Lina,Wu Tao,Liu Haichao
Abstract
Abstract
Background
Brucellosis is a common zoonotic disease that may have a variety of clinical manifestations when it affects the nervous system. Ischemic stroke is a rare clinical symptom, but if it is not diagnosed and treated early, it may cause more severe consequences.
Case presentation
We report a 38-year-old man presenting with hearing impairment for four years and sudden weakness of the right limb for two years, recurrent aphasia, and gradual weakness of bilateral lower limbs for nine months. He had bilateral positive Babinski’s sign. Cerebrospinal fluid (CSF) showed raised protein and pleocytosis. Magnetic resonance imaging (MRI) showed ischemic infarcts in the pons and extensive enhancement of spinal meninges combined with spinal cord atrophy and ischemia. The tests revealed Brucella Rose Bengal positive in serum and CSF. Brucella culture in CSF was also positive. Next-generation sequencing (NGS) of CSF revealed positive for Brucella with 105 species were detected. He showed significant improvement with antibiotics at five months follow-up.
Conclusions
Neurobrucellosis may mimic stroke and transverse myelitis like syndromes. NB is a treatable infectious condition and should always be considered in the differentials, especially if there are risk factors, as in our case.
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Reference23 articles.
1. Chomel BB, Debess EE, Mangiamele DM, Reilly KF, Farver TB, Sun RK, et al. Changing Trends In The Epidemiology Of Human Brucellosis In California From 1973 To 1992: A Shift Toward Foodborne Transmission. J Infect Dis. 1994;170:1216–23.
2. Tarfarosh SFA, Manzoor M. Neurological Manifestations of Brucellosis in an Indian Population. Cureus. 2016;8:e684.
3. Karsen H, Koruk ST, Duygu F, Yapici K, Kati M. Review of 17 cases of neurobrucellosis: clinical manifestations, diagnosis, and management. Arch Iran Med. 2012;15:491–4.
4. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14:e469–78.
5. Gul HC, Erdem H, Bek S. Overview of neurobrucellosis: a pooled analysis of 187 cases. Int J Infect Dis. 2009;13:e339–43.
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