Author:
Andersen Naja H.,Blauenfeldt Rolf A.,Mikkelsen Ronni,Simonsen Claus Z.
Abstract
Abstract
Background
We present a case illustrating evolution of symptoms and brain magnetic resonance imaging in cortical superficial siderosis.
Case presentation
A 74-year-old man with no prior medical history presented with transient focal neurological episodes with subtle imaging changes. There was no evidence of cortical superficial siderosis. Two weeks later, the patient was readmitted with new episodes, and had developed cortical superficial siderosis adjacent to a cerebral microbleed. Transient focal neurological episode secondary to cortical superficial siderosis was diagnosed together with probable cerebral amyloid angiopathy.
Conclusion
Clinical symptoms may precede the development of cortical superficial siderosis prior to being detectable on brain MRI. This case highlights the temporal development of cortical superficial siderosis.
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Reference8 articles.
1. A Charidimou, Q Gang, and DJ Werring, “Sporadic cerebral amyloid angiopathy revisited: Recent insights into pathophysiology and clinical spectrum,” Journal of Neurology, Neurosurgery and Psychiatry, 83, 2. BMJ Publishing Group, pp. 124–137, 2012. doi: https://doi.org/10.1136/jnnp-2011-301308.
2. A Charidimou et al., “The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study,” 2022. [Online]. Available: www.thelancet.com/neurology
3. A Charidimou et al., “Cortical superficial siderosis: Detection and clinical significance in cerebral amyloid angiopathy and related conditions,” Brain, 138, 8. Oxford University Press, pp. 2126–2139, Aug. 01, 2015. doi: https://doi.org/10.1093/brain/awv162.
4. Feldman HH, Maia LF, MacKenzie IRA, Forster BB, Martzke J, Woolfenden A. Superficial siderosis: A potential diagnostic marker of cerebral amyloid angiopathy in alzheimer disease. Stroke. 2008;39:10. https://doi.org/10.1161/STROKEAHA.107.510826.
5. Pongpitakmetha T, et al. Cortical superficial siderosis progression in cerebral amyloid angiopathy: Prospective MRI study. Neurology. 2020;94(17):E1853–65. https://doi.org/10.1212/WNL.0000000000009321.