Author:
Deijle Inger A.,Hemmes Roelofjan,Boss H. Myrthe,de Melker Edwin C.,van den Berg Bob T. J.,Kwakkel Gert,van Wegen Erwin,Bosboom Wendy M.,Weinstein Henry C.,van Schaik Sander M.,Van den Berg-Vos Renske M.
Abstract
Abstract
Background
Patients with a transient ischemic attack (TIA) or ischemic stroke are at increased risk of developing cognitive impairment in the subacute phase. At present, the effects of exercise on cognitive functioning following a TIA or stroke are not fully known. The purpose of this trial was to investigate the effect of exercise on global cognition.
Methods
The MoveIT trial is a single-centre, observer-blinded, randomized controlled trial involving a 1-year exercise intervention consisting of a 12-week group exercise program, combined with three counselling visits to the physiotherapists over a 9-month period. The control group received standard care. The primary outcome was global cognitive functioning, assessed at one year, using the Montreal Cognitive Assessment (MoCA). Secondary outcomes included cardiorespiratory fitness, the cardiovascular profile, and attainment of secondary prevention targets, anxiety, depression and fatigue at one and two years.
Results
The experimental group consisted of 60 patients, while the control group consisted of 59 patients. The mean age was 64.3 years and 41% were female. No between-group differences were found on global cognitive functioning (MD, 0.7 out of 30, 95% CI, − 0.2 to 1.6) or on secondary outcome measures at 12 months. The only significant between-group difference was found for fatigue, in favour of the experimental group at 12 months (MD, 0.6 out of 63, 95% CI, 0.1 to 1.1).
Conclusions
No benefit of this exercise intervention was found regarding global cognition. Future studies need to focus on optimizing rehabilitation strategies for this vulnerable group of patients.
Trial registration
http://www.trialregister.nl. Unique identifier: NL3721.
Date first registration: 06-03-2013.
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
10 articles.
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