Author:
Liu Chi-Hung,Chang Joseph Tung-Chieh,Lee Tsong-Hai,Chang Pi-Yueh,Chang Chien-Hung,Wu Hsiu-Chuan,Chang Ting-Yu,Huang Kuo-Lun,Lin Chien-Yu,Fan Kang-Hsing,Chang Yeu-Jhy
Abstract
Abstract
Background
Hypothyroidism (HT) and carotid artery stenosis (CAS) are complications of radiotherapy (RT) in patients with head and neck cancer (HNC). The impact of post-RT HT on CAS progression remains unclear.
Methods
Between 2013 and 2014, HNC patients who had ever received RT and were under regular follow-up in our hospital were initially screened. Patients were categorized into euthyroid (EU) and HT groups. Details of RT and HNC were recorded. Total plaque scores and degrees of CAS were measured during annual extracranial duplex follow-up. Patients were monitored for CAS progression to > 50 % stenosis or ischemic stroke (IS). Cumulative time to CAS progression and IS between the 2 groups were compared. Data were further analyzed based on the use or nonuse of thyroxine of the HT group.
Results
333 HNC patients with RT history were screened. Finally, 216 patients were recruited (94 and 122 patients in the EU and HT groups). Patients of the HT group received higher mean RT doses (HT vs. EU; 7021.55 ± 401.67 vs. 6869.69 ± 425.32 centi-grays, p = 0.02). Multivariate Cox models showed comparable CAS progression (p = 0.24) and IS occurrence (p = 0.51) between the 2 groups. Moreover, no significant difference was observed in time to CAS progression (p = 0.49) or IS (p = 0.31) among patients with EU and HT using and not using thyroxine supplement.
Conclusions
Our results did not demonstrate significant effects of HT and thyroxine supplementation on CAS progression and IS incidence in patients with HNC after RT.
Funder
Chang Gung Memorial Hospital
Ministry of Science and Technology, Taiwan
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
2 articles.
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