Author:
Yang Bo,Guo Lei,Yang Xu,Yu Nengwei
Abstract
Abstract
Background
Posterior reversible encephalopathy syndrome (PRES) is a rare disease characterized by reversible subcortical vasogenic brain edema. Neuromyelitis optica spectrum disorder (NMOSD) is a frequent neurological autoimmune disease that is rarely reported to complicate PRES.
Case presentation
Here, we report a case of neuromyelitis optica (NMO) concurrent with PRES. A 50-year-old woman presented with severe impairment of her health visual acuity, with significantly worsening of the motor weakness in both lower limbs during methylprednisolone therapy after her diagnosis of NMO. MRI showed new-onset brain edematous lesions of the bilateral frontal, occipital, and parietal lobes. PRES was considered. Her vision impairment and weakness of the extremities were alleviated after antihypertensive treatment and dehydration. The edema lesions detected by MRI also completely disappeared.
Conclusions
We reviewed 14 cases of NMO with PRES and concluded that the etiology of NMOSD concurrent PRES may be multifactorial, involving pathogenic IgGs against aquaporin-4 (AQP-4) and immunotherapy treatment. Different underlying pathogeneses require different treatment approaches.
Funder
Major science and technology application demonstrat- ion project of Chengdu Science and Technology Bureau, Sichuan Province
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
2 articles.
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1. Delayed diagnosis of the neuromyelitis optica spectrum disorder;Neurology, Neuropsychiatry, Psychosomatics;2023-08-21
2. Methylprednisolone;Reactions Weekly;2023-01-21