Author:
Luo Hui,Jin Jing,Jin Jiajia,Lou Kecheng,He Hailan,Feng Shangzhi,Zeng Fei,Zou Junrong
Abstract
AbstractExtracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers.
Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory diseases, fibrosis, and cancer, but they are also essential mediators in immunomodulation, cancer treatment, infectious defense, and tissue repair. In this review, we emphasize recent advances in oncology therapy using macrophage EVs, mesenchymal stem cell EVs, milk EVs, and plant EVs, as well as the advantages of EVs as delivery platforms and their prospective clinical applications and use.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangxi Province
Medjaden Young Scientist Fund
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry,Pharmaceutical Science,Oncology,Biomedical Engineering
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