Advances in blood–brain barrier-crossing nanomedicine for anti-glioma

Author:

Liu Dongdong,Dai Xingliang,Tao Zhenchao,Zhou Hu,Hong Wenqing,Qian Haisheng,Cheng Hongwei,Wang Xianwen

Abstract

AbstractGlioma is the most prevalent type of primary brain tumor, and glioblastoma multiforme (GBM) is the highest and most deadly type of primary central nervous system (CNS) tumor, affecting a significant number of patients each year, with a median overall survival of approximately 14.6 months after diagnosis. Despite intensive treatment, nearly all GBM patients experience recurrence, with a 5-year survival rate of about 5%. The protective BBB and high tumor heterogeneity prevent the effective delivery of drugs, resulting in the treatment failure of various drugs. The emergence of nanometer-scale diagnosis and treatment methods has provided new promising approaches to overcome these difficulties. Thus, our review focuses on the development of BBB-crossing nanomedicine-enhanced chemotherapy and combined therapy applications for glioma. Meanwhile, we also reviewed the strategies to overcome the blood–brain barrier. Additionally, we discuss recent achievements in the area of brain tumor treatment with nanomedicine and the rational design approach, which will offer recommendations for anti-GBM nanomedicine development.

Funder

Anhui Provincial Natural Science Foundation

the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University

the National Natural Science Foundation of China

the Research Fund of Anhui Institute of translational medicine

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry,Pharmaceutical Science,Oncology,Biomedical Engineering

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