Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size

Author:

Zaki Zakiyyah Munirah Mohd,Kuroda Anri,Morimura Naoko,Hayashi Yoshitaka,Hitoshi SeijiORCID

Abstract

AbstractNeural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal’s lifespan. NSCs in the subependymal zone infrequently divide and generate transit amplifying cells, which are destined to become olfactory bulb neurons. When transit amplifying cells are depleted, they are replenished by the quiescent NSC pool. However, the cellular basis for this recovery process remains largely unknown. In this study, we traced NSCs and their progeny after transit amplifying cells were eliminated by intraventricular infusion of cytosine β-D-arabinofuranoside. We found that although the number of neurosphere-forming NSCs decreased shortly after the treatment, they were restored to normal levels 3 weeks after the cessation of treatment. More importantly, the depletion of transit amplifying cells did not induce a significant expansion of the NSC pool by symmetric divisions. Our data suggest that the size of the NSC pool is hardly affected by brain damage due to antimitotic drug treatment.

Funder

Ministry of Education, Culture, Sports, Science and Technology of Japan

SENSHIN Medical Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Physiology

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