Author:
Hosseini Seyedeh Marzieh,Farashi Sajjad,Bashirian Saeid
Abstract
Abstract
Purpose
Tremor is one of the key characteristics of Parkinson’s disease (PD), leading to physical disabilities and often showing limited responses to pharmacological treatments. To suppress tremors in PD patients, several types of non-invasive and non-pharmacological methods have been proposed so far. In the current systematic review, three electromagnetic-based radiation strategies including electrical stimulation, magnetic stimulation, and light stimulation methods were reviewed and compared.
Methods
Major databases were searched to retrieve eligible studies. For the meta-analysis, a random-effect Bayesian framework was used. Also, heterogeneity between studies was assessed using I2 statistic, prediction interval, and tau2. Publication bias was assessed using funnel plot, and the effectiveness of methods for reducing tremor was compared using network Bayesian meta-analysis.
Results and conclusion
Thirty-one studies were found for qualitative analysis, and 16 studies were found for quantitative synthesis. Based on the suppression ratio, methods can be ordered as electrical stimulation, light therapy, and magnetic stimulation. Furthermore, the results showed that electrical and magnetic stimulation were more effective for tremor suppression at early stages of PD, while light therapy was found to be more effective during the later stages of PD.
Funder
Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences
Publisher
Springer Science and Business Media LLC
Subject
Health Informatics,Rehabilitation
Reference67 articles.
1. Farashi S. Distinguishing between Parkinson’s disease patients and healthy individuals using a comprehensive set of time, frequency and time-frequency features extracted from vertical ground reaction force data. Biomed Signal Process Control. 2020;62:102132. https://doi.org/10.1016/j.bspc.2020.102132
2. Farashi S. Analysis of vertical eye movements in Parkinson’s disease and its potential for diagnosis. Appl Intell. 2021;51(11):8260–70. https://doi.org/10.1007/s10489-021-02364-9
3. Riviere CN, Rader RS, Thakor NV. Adaptive cancelling of physiological tremor for improved precision in microsurgery. IEEE Trans Biomed Eng. 1998;45(7):839–46. https://doi.org/10.1109/10.686791
4. Ang WT, Pradeep P, Riviere C, editors. Active tremor compensation in microsurgery. Engineering in Medicine and Biology Society, 2004 IEMBS’04 26th Annual International Conference of the IEEE; 2004: IEEE.
5. Hosseini S, Al-Jumaily A, Kalhori H, editors. Tremor suppression in wrist joint using active force control method. 9th Australasian Congress on Applied Mechanics, ACAM 2017; 2017.