A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

Author:

Pontikos Nikolas,Smyth Deborah J,Schuilenburg Helen,Howson Joanna MM,Walker Neil M,Burren Oliver S,Guo Hui,Onengut-Gumuscu Suna,Chen Wei-Min,Concannon Patrick,Rich Stephen S,Jayaraman Jyothi,Jiang Wei,Traherne James A,Trowsdale John,Todd John A,Wallace Chris

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Biotechnology

Reference24 articles.

1. Jiang W, Johnson C, Jayaraman J, Simecek N, Noble J, Moffatt MF, Cookson WO, Trowsdale J, Traherne JA: Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. Genome Res. 2012, 22 (10): 1845-1854. 10.1101/gr.137976.112.

2. Gumperz JE, Barber LD, Valiante NM, Percival L, Phillips JH, Lanier LL, Parham P: Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor. J Immunol. 1997, 158 (11): 5237-5241.

3. Vivian JP, Duncan RC, Berry R, O’Connor GM, Reid HH, Beddoe T, Gras S, Saunders PM, Olshina MA, Widjaja JML, Harpur CM, Lin J, Maloveste SM, Price DA, Lafont BAP, McVicar DW, Clements CS, Brooks AG, Rossjohn J: Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature. 2011, 479 (7373): 401-405. 10.1038/nature10517.

4. Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, O’Brien SJ, Walker BD, Parham P, Deeks SG, McVicar DW, Carrington M: Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet. 2007, 39 (6): 733-740. 10.1038/ng2035.

5. Martin MP, Gao X, Lee JH, Nelson GW, Detels R, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, Trowsdale J, Wilson M, O’Brien SJ, Carrington M: Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002, 31 (4): 429-434.

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