Functional genomics reveals that Clostridium difficileSpo0A coordinates sporulation, virulence and metabolism

Author:

Pettit Laura J,Browne Hilary P,Yu Lu,Smits Wiep Klaas,Fagan Robert P,Barquist Lars,Martin Melissa J,Goulding David,Duncan Sylvia H,Flint Harry J,Dougan Gordon,Choudhary Jyoti S,Lawley Trevor D

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Biotechnology

Reference73 articles.

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2. Walker AS, Eyre DW, Wyllie DH, Dingle KE, Harding RM, O’Connor L, Griffiths D, Vaughan A, Finney J, Wilcox MH, Crook DW, Peto TE: Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing. PLoS Med. 2012, 9 (2): e1001172-10.1371/journal.pmed.1001172.

3. He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, Connor TR, Harris SR, Fairley D, Bamford KB, D'Arc S, Brazier J, Brown D, Coia JE, Douce G, Gerding D, Kim HJ, Koh TH, Kato H, Senoh M, Louie T, Michell S, Butt E, Peacock SJ, Brown NM, Riley T, Songer G, Wilcox M, Pirmohamed M, Kuijper E, et al: Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet. 2012, 45 (1): 109-113. 10.1038/ng.2478.

4. He M, Sebaihia M, Lawley TD, Stabler RA, Dawson LF, Martin MJ, Holt KE, Seth-Smith HM, Quail MA, Rance R, Brooks K, Churcher C, Harris D, Bentley SD, Burrows C, Clark L, Corton C, Murray V, Rose G, Thurston S, van Tonder A, Walker D, Wren BW, Dougan G, Parkhill J: Evolutionary dynamics of Clostridium difficile over short and long time scales. Proc Natl Acad Sci USA. 2010, 107 (16): 7527-7532. 10.1073/pnas.0914322107.

5. Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeno-Tarraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, et al: The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet. 2006, 38 (7): 779-786. 10.1038/ng1830.

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