Author:
Marquez Christine Ardelle,Oh Cho-Im,Ahn Gna,Shin Woo-Ri,Kim Yang-Hoon,Ahn Ji-Young
Abstract
AbstractWith the immense progress in drug delivery systems (DDS) and the rise of nanotechnology, challenges such as target specificity remain. The vesicle-vector system (VVS) is a delivery system that uses lipid-based vesicles as vectors for a targeted drug delivery. When modified with target-probing materials, these vesicles become powerful vectors for drug delivery with high target specificity. In this review, we discuss three general types of VVS based on different modification strategies: (1) vesicle-probes; (2) vesicle-vesicles; and (3) genetically engineered vesicles. The synthesis of each VVS type and their corresponding properties that are advantageous for targeted drug delivery, are also highlighted. The applications, challenges, and limitations of VVS are briefly examined. Finally, we share a number of insights and perspectives regarding the future of VVS as a targeted drug delivery system at the nanoscale.
Graphical Abstract
Funder
National Research Foundation of Korea
Commercializations Promotion Agency for R and D Outcomes
Publisher
Springer Science and Business Media LLC
Cited by
5 articles.
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