Exosome-based engineering strategies for the diagnosis and treatment of oral and maxillofacial diseases

Author:

Ren Jianing,Jing Xuan,Liu Yingyu,Liu Jinrong,Ning Xiao,Zong Mingrui,Zhang Ran,Cheng Huaiyi,Cui Jiayu,Li Bing,Wu Xiuping

Abstract

AbstractOral and maxillofacial diseases are one of the most prevalent diseases in the world, which not only seriously affect the health of patients’ oral and maxillofacial tissues, but also bring serious economic and psychological burdens to patients. Therefore, oral and maxillofacial diseases require effective treatment. Traditional treatments have limited effects. In recent years, nature exosomes have attracted increasing attention due to their ability to diagnose and treat diseases. However, the application of nature exosomes is limited due to low yield, high impurities, lack of targeting, and high cost. Engineered exosomes can be endowed with better comprehensive therapeutic properties by modifying exosomes of parent cells or directly modifying exosomes, and biomaterial loading exosomes. Compared with natural exosomes, these engineered exosomes can achieve more effective diagnosis and treatment of oral and maxillary system diseases, and provide reference and guidance for clinical application. This paper reviews the engineering modification methods of exosomes and the application of engineered exosomes in oral and maxillofacial diseases and looks forward to future research directions. Graphical Abstract

Funder

Science and technology innovation project of colleges and universities in Shanxi Province

Shanxi Province Basic Research Plan

This work is supported by Science and Technology Innovation Leader and Key Talent Team Project of Shanxi Province

Key Research and Development Plan of Shanxi Province

Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province

Key national science and technology cooperation project of Shanxi Provincial Department of Science and Technology

Scientific Research Project for Returned Overseas Professionals of Shanxi Province

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3