Author:
Ren Jianing,Jing Xuan,Liu Yingyu,Liu Jinrong,Ning Xiao,Zong Mingrui,Zhang Ran,Cheng Huaiyi,Cui Jiayu,Li Bing,Wu Xiuping
Abstract
AbstractOral and maxillofacial diseases are one of the most prevalent diseases in the world, which not only seriously affect the health of patients’ oral and maxillofacial tissues, but also bring serious economic and psychological burdens to patients. Therefore, oral and maxillofacial diseases require effective treatment. Traditional treatments have limited effects. In recent years, nature exosomes have attracted increasing attention due to their ability to diagnose and treat diseases. However, the application of nature exosomes is limited due to low yield, high impurities, lack of targeting, and high cost. Engineered exosomes can be endowed with better comprehensive therapeutic properties by modifying exosomes of parent cells or directly modifying exosomes, and biomaterial loading exosomes. Compared with natural exosomes, these engineered exosomes can achieve more effective diagnosis and treatment of oral and maxillary system diseases, and provide reference and guidance for clinical application. This paper reviews the engineering modification methods of exosomes and the application of engineered exosomes in oral and maxillofacial diseases and looks forward to future research directions.
Graphical Abstract
Funder
Science and technology innovation project of colleges and universities in Shanxi Province
Shanxi Province Basic Research Plan
This work is supported by Science and Technology Innovation Leader and Key Talent Team Project of Shanxi Province
Key Research and Development Plan of Shanxi Province
Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province
Key national science and technology cooperation project of Shanxi Provincial Department of Science and Technology
Scientific Research Project for Returned Overseas Professionals of Shanxi Province
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering