Author:
Yu Yang,Sun Houyi,Lu Qunshan,Sun Junyuan,Zhang Pengfei,Zeng Linran,Vasilev Krasimir,Zhao Yunpeng,Chen Yu,Liu Peilai
Abstract
AbstractProlonged and incurable bacterial infections in soft tissue and bone are currently causing large challenges in the clinic. Two-dimensional (2D) materials have been designed to address these issues, but materials with satisfying therapeutic effects are still needed. Herein, CaO2-loaded 2D titanium carbide nanosheets (CaO2-TiOx@Ti3C2, C-T@Ti3C2) were developed. Surprisingly, this nanosheet exhibited sonodynamic ability, in which CaO2caused the in situ oxidation of Ti3C2MXene to produce acoustic sensitiser TiO2on its surface. In addition, this nanosheet displayed chemodynamic features, which promoted a Fenton reaction triggered by self-supplied H2O2. We detected that C-T@Ti3C2nanosheets increased reactive oxygen species (ROS) production in response to sonodynamic therapy, which displayed an ideal antibacterial effect. Furthermore, these nanoreactors facilitated the deposition of Ca2+, which promoted osteogenic transformation and enhanced bone quality in osteomyelitis models. Herein, a wound healing model and prosthetic joint infection (PJI) model were established, and the C-T@Ti3C2nanosheets played a protective role in these models. Taken together, the results indicated that the C-T@Ti3C2nanosheets function as a multifunctional instrument with sonodynamic features, which might reveal information regarding the treatment of bacterial infections during wound healing.Graphical Abstract
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Shanghai Science and Technology Program
Basic Research Program of Shanghai Municipal Government
International Collaboration Project of Chinese Academy of Sciences
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Cited by
9 articles.
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