New frontiers in salivary extracellular vesicles: transforming diagnostics, monitoring, and therapeutics in oral and systemic diseases

Author:

Cui Li,Zheng Jiarong,Lu Ye,Lin Pei,Lin Yunfan,Zheng Yucheng,Xu Rongwei,Mai Zizhao,Guo Bing,Zhao Xinyuan

Abstract

AbstractSalivary extracellular vesicles (EVs) have emerged as key tools for non-invasive diagnostics, playing a crucial role in the early detection and monitoring of diseases. These EVs surpass whole saliva in biomarker detection due to their enhanced stability, which minimizes contamination and enzymatic degradation. The review comprehensively discusses methods for isolating, enriching, quantifying, and characterizing salivary EVs. It highlights their importance as biomarkers in oral diseases like periodontitis and oral cancer, and underscores their potential in monitoring systemic conditions. Furthermore, the review explores the therapeutic possibilities of salivary EVs, particularly in personalized medicine through engineered EVs for targeted drug delivery. The discussion also covers the current challenges and future prospects in the field, emphasizing the potential of salivary EVs in advancing clinical practice and disease management.

Funder

National Natural Science Foundation of China

Science Research Cultivation Program of Stomatological Hospital, Southern Medical University

Young Top-notch Talent of Pearl River Talent Plan

Guangdong Provincial Science and Technology Project Foundation

Scientific Research Talent Cultivation Project of Stomatological Hospital, Southern Medical University

Publisher

Springer Science and Business Media LLC

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