Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury-Reference-Cited by-同舟云学术

Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

Published:2022-02-02 Issue:1 Volume:20 Page:
ISSN:1477-3155
Container-title:Journal of Nanobiotechnology
language:en
Short-container-title:J Nanobiotechnol

Author:

Liu Chao,Hu Fanqi,Jiao Genlong,Guo Yue,Zhou Pan,Zhang Yuning,Zhang Zhen,Yi Jing,You Yonggang,Li Zhizhong,Wang Hua,Zhang Xuesong

Abstract

AbstractStem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of M1 macrophage polarization are not known. Herein, we demonstrated that ROS can induce M1 macrophage polarization and have a concentration-dependent effect. ROS can induce M1 macrophage polarization through the MAPK-NFκB P65 signaling pathway. Dental pulp stem cell (DPSC)-derived exosomes can reduce macrophage M1 polarization through the ROS-MAPK-NFκB P65 signaling pathway in treating SCI. This study suggested that DPSC-derived exosomes might be a potential drug for treating SCI. Disruption of the cycle between ROS and M1 macrophage polarization might also be a potential effective treatment by reducing secondary damage. Graphical Abstract

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering

Link

https://link.springer.com/content/pdf/10.1186/s12951-022-01273-4.pdf

Reference67 articles.

1. Dutta D, Khan N, Wu J, Jay SM. Extracellular vesicles as an emerging frontier in spinal cord injury pathobiology and therapy. Trends Neurosci. 2021;44(6):492–506. https://doi.org/10.1016/j.tins.2021.01.003.

2. Li L, Zhang Y, Mu J, et al. Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury. Nano Lett. 2020;20(6):4298–305. https://doi.org/10.1021/acs.nanolett.0c00929.

3. Guo S, Perets N, Betzer O, et al. Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury. ACS Nano. 2019;13(9):10015–28. https://doi.org/10.1021/acsnano.9b01892.

4. Kim HY, Kumar H, Jo MJ, et al. Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment. Nano Lett. 2018;18(8):4965–75. https://doi.org/10.1021/acs.nanolett.8b01816.

5. Xu P, Zhang F, Chang MM, et al. (2021) Recruitment of γδ T cells to the lesion via the CCL2/CCR2 signaling after spinal cord injury. J Neuroinflammation. 2021;18(1):64. https://doi.org/10.1186/s12974-021-02115-0.

Cited by 72 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enhancing bone regeneration and immunomodulation via gelatin methacryloyl hydrogel-encapsulated exosomes from osteogenic pre-differentiated mesenchymal stem cells;Journal of Colloid and Interface Science;2024-10

2. Specific cell subclusters of dental pulp stem cells respond to distinct pathogens through the ROS pathway;Frontiers in Cellular and Infection Microbiology;2024-09-12

3. Prussian blue nanotechnology in the treatment of spinal cord injury: application and challenges;Frontiers in Bioengineering and Biotechnology;2024-09-11

4. Targeting G6PD to mitigate cartilage inflammation in TMJOA: The NOX4-ROS-MAPK axis as a therapeutic avenue;International Immunopharmacology;2024-09

5. Design, synthesis and biological evaluation of novel naphthoquinothiazole derivatives as potent antitumor agents through inhibiting STAT3;Bioorganic Chemistry;2024-09