Author:
Li Congsun,Wang Jie,Yang Weinan,Yu Kang,Hong Jianqiao,Ji Xiaoxiao,Yao Minjun,Li Sihao,Lu Jinwei,Chen Yazhou,Yan Shigui,Wu Haobo,Ma Chiyuan,Yu Xiaohua,Jiang Guangyao,Liu An
Abstract
AbstractLong-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which is a common method for treating tendinopathy, has positive effects on tendon repair. In addition, tendon-derived stem cells (TDSCs), which are stem cells located in tendons, play a major role in maintaining tissue homeostasis and postinjury repair. In this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP–TDSC–GM) were prepared by a projection-based 3D bioprinting technique. Our results showed that PRP–TDSC–GM could promote tendon differentiation in TDSCs and reduce the inflammatory response by downregulating the PI3K–AKT pathway, thus promoting the structural and functional repair of tendons in vivo.
Graphical Abstract
Funder
National Natural Science Foundation of China
Young Scientist Fund of the National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Cited by
9 articles.
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