Author:
Huang Shengnan,Xu Zhiling,Zhi Weiwei,Li Yijing,Hu Yurong,Zhao Fengqin,Zhu Xiali,Miao Mingsan,Jia Yongyan
Abstract
AbstractBreast cancer remains a malignancy that poses a serious threat to human health worldwide. Chemotherapy is one of the most widely effective cancer treatments in clinical practice, but it has some drawbacks such as poor targeting, high toxicity, numerous side effects, and susceptibility to drug resistance. For auto-amplified tumor therapy, a nanoparticle designated GDTF is prepared by wrapping gambogic acid (GA)-loaded dendritic porous silica nanoparticles (DPSNs) with a tannic acid (TA)-Fe(III) coating layer. GDTF possesses the properties of near-infrared (NIR)-enhanced and pH/glutathione (GSH) dual-responsive drug release, photothermal conversion, GSH depletion and hydroxyl radical (·OH) production. When GDTF is exposed to NIR laser irradiation, it can effectively inhibit cell proliferation and tumor growth both in vitro and in vivo with limited toxicity. This may be due to the synergistic effect of enhanced tumor accumulation, and elevated reactive oxygen species (ROS) production, GSH depletion, and TrxR activity reduction. This study highlights the enormous potential of auto-amplified tumor therapy.
Funder
National Natural Science Foundation of China
the Scientific and Technological Project of Henan Province
Postdoctoral Research Grant in Henan Province
Open Fund of Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Henan Province
the Key Scientific Research Project of Colleges and Universities in Henan Province
Publisher
Springer Science and Business Media LLC