Author:
Xie Qian,Xu Haoran,Wan Qin
Abstract
Abstract
Aims
The purpose of the present study was to investigate the correlation between the number of live-birth pregnancies and metabolic syndrome (MetS) in Chinese women according to menstruation history.
Methods
Registry data for all pregnancies in a cohort of 6157 Chinese women aged 40 years or older were obtained and the number of live-birth pregnancies were enumerated. We defined MetS using five criteria: impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension. Multivariate logistic regression analysis was conducted to assess potential risk factors for MetS. Postmenopausal women with three or more of live-birth pregnancies had the highest prevalence of MetS (P < 0.05).
Results
Among the 6157 females aged 40 years or older in Luzhou city, 2143 (34.8%) participants had incident MetS. The number of live-birth pregnancies was significantly correlated with age and fasting blood glucose (FBG) level (P < 0.05). The prevalence of MetS increased with the number of live-birth pregnancies (P < 0.01), and the frequency in postmenopausal women was significantly higher than that in premenopausal women (P < 0.001). In the binary logistic regression model, menopausal status [OR = 0.343 (0.153–0.769), P < 0.001] were significantly associated with an increased risk of MetS.
Conclusions
The number of live-birth pregnancies is correlated with an increased risk of MetS in Chinese women aged 40 years and over, especially in postmenopausal women. Greater attention should be paid to postmenopausal women who have had multiple live-birth pregnancies with a view to intervening early to prevent related diseases.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Endocrinology, Diabetes and Metabolism
Reference39 articles.
1. Azizi F, Hadaegh F, Khalili D, Esteghamati A, Hosseinpanah F, Delavari A, et al. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian National Committee of obesity. Arch Iran Med. 2010;13(5):426–8.
2. Vidigal Fde C, Ribeiro AQ, Babio N, et al. Prevalence of metabolic syndrome and pre-metabolic syndrome in health professionals: LATINMETS Brazil study. Diabetol Metab Syndr. 2015;7(1):1758–5996. https://doi.org/10.1186/s13098-015-0003-x.
3. Vahid S, Sahar G, Mohammadtaghi S, et al. The frequency of metabolic syndrome among female patients admitted in psychiatry ward. Med J Mashhad Univ Med Sci. 2012;54:230–7.
4. Li R, Li W, Lun Z, et al. Prevalence of metabolic syndrome in mainland China: a meta-analysis of published studies. BMC Public Health. 2016 Apr 01;16(1):296. https://doi.org/10.1186/s12889-016-2870-y.
5. Sy RG, Llanes EJ, Reganit PF, et al. Socio-demographic factors and the prevalence of metabolic syndrome among filipinos from the LIFECARE cohort. J Atheroscler Thromb. 2014;21(1):S9–17. https://doi.org/10.5551/jat.21_Sup.1-S9.
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