Abstract
Abstract
Background
Atrial natriuretic peptide (ANP) is a cardiovascular and metabolic hormone that has been identified recently as being associated with chronic kidney disease (CKD) without diabetes. Cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin (ADP) contribute to the development of type 2 diabetes (T2DM). The aim here was to investigate the relationships of ANP with cytokine levels and clinical variables in T2DM nephropathy patients.
Methods
A total of 81 participants with T2DM were recruited, including 37 patients with normoalbuminuria, 23 patients with microalbuminuria and 21 patients with macroalbuminuria. Serum concentrations of ANP and cytokines were measured using enzyme-linked immunosorbent assay (ELISA) kits. The correlations between ANP and clinical variables were analyzed. Multiple linear regression and logistic regression models were constructed to test the associations between ANP and the severity and presence of albuminuria.
Results
The macroalbuminuria patients exhibited higher plasma levels of ANP, TNF-α, IL-6, and ADP; higher serum creatinine (Cr) and blood urea nitrogen (BUN); and longer duration of diabetes mellitus (DM) than the patients with normoalbuminuria and microalbuminuria. Plasma ANP level was significantly associated with TNF-α (r = 0.876, p < 0.001), IL-6 (r = 0.816, p < 0.001) and ADP (r = 0.772, p < 0.001), independent of the duration of DM or the BUN concentration.
Conclusion
ANP is higher in type 2 diabetes mellitus nephropathy subjects, especially those who have macroalbuminuria, which is associated with compensatory responses to inflammation.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Endocrinology, Diabetes and Metabolism
Reference38 articles.
1. Kausik U, Julia BL. Update on diabetic nephropathy: Core curriculum 2018. Am J Kidney Dis. 2018;71(6):884–95.
2. Annabelle MW, Søren TK, Mark EC. Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies. Expert Opin Ther Targets. 2019;23(7):579–91.
3. Rui T, You MA, Hye YK, Yun JL, Kyung WC, Dae GK, et al. Atrial secretion of ANP is suppressed in renovascular hypertension: shifting of ANP secretion from atria to the left ventricle. Am J Physiol Heart Circ Physiol. 2018;315(3):H590–601.
4. Chiaki NO, Kenji K, Naoto M. Three molecular forms of atrial natriuretic peptides: quantitative analysis and biological characterization. J Pept Sci. 2017;23(7–8):486–95.
5. Tomoko I, John CB. Atrial natriuretic peptide - old but new therapeutic in cardiovascular diseases. Circ J. 2017;81(7):913–9.
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