Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor
Author:
Funder
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
Environmental Science (miscellaneous),Genetics,Social Psychology
Link
http://link.springer.com/content/pdf/10.1186/s41021-017-0076-x.pdf
Reference55 articles.
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3. Hecht SS. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol. 2002;3:461–9.
4. Sims P, Grover PL, Swaisland A, Pal K, Hewer A. Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide. Nature. 1974;252:326–8.
5. Thakker DR, Yagi H, Lu AY, Levin W, Conney AH. Metabolism of benzo[a]pyrene: conversion of (+/−)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides. Proc Natl Acad Sci U S A. 1976;73:3381–5.
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