Author:
Ma Rui-ting,Wang Yuanyuan,Ji Feng,Chen Jian-nan,Wang Tian-jun,Liu Yan,Hou Ming-xing,Guo Zhi-gang
Abstract
Abstract
Background
Investigating the unexplored territory of lncRNA m6A modification in colorectal cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1.
Methods
Clinical assessments reveal upregulated LINC01106 promoting vascular generation via the miR-449b-5p-VEGFA pathway.
Results
YTHDF1, elevated in CRC tissues, emerges as an adverse prognostic factor. Functional experiments showcase YTHDF1’s inhibitory effects on CRC cell dynamics. Mechanistically, Me-CLIP identifies m6A-modified LINC01106, validated as a YTHDF1 target through Me-RIP.
Conclusions
This study sheds light on the YTHDF1-mediated m6A modification of LINC01106, presenting it as a key player in suppressing CRC vascular generation.
Funder
National Natural Science Foundation of China
The Graduate Scientific Research and Practical Innovation in Jiangsu Province plan
The Inner Monglia Natural Science Foundation
Inner Mongolia Autonomous Region Health Commission, medical and health science and technology Plan project
Inner Mongolia Science and Technology Department plan project
Publisher
Springer Science and Business Media LLC