Author:
Mo Jia-qian,Zhang Shen-yan,Li Qiang,Chen Mo-xian,Zheng Yue-qing,Xie Xin,Zhang Rongxin,Wang Shan-shan
Abstract
AbstractAccording to statistics, the incidence of liver cancer is increasing yearly, and effective treatment of liver cancer is imminent. For early liver cancer, resection surgery is currently the most effective treatment. However, resection does not treat the disease in advanced patients, so finding a method with a better prognosis is necessary. In recent years, ferroptosis and cuproptosis have been gradually defined, and related studies have proved that they show excellent results in the therapy of liver cancer. Cuproptosis is a new form of cell death, and the use of cuproptosis combined with ferroptosis to inhibit the production of hepatocellular carcinoma cells has good development prospects and is worthy of in-depth discussion by researchers. In this review, we summarize the research progress on cuproptosis combined with ferroptosis in treating liver cancer, analyze the value of cuproptosis and ferroptosis in the immune of liver cancer, and propose potential pathways in oncotherapy with the combination of cuproptosis and ferroptosis, which can provide background knowledge for subsequent related research.
Funder
Administration of traditional Chinese medicine of Guangdong Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
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