Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer
Author:
Funder
National High Level Hospital Clinical Research Funding
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1186/s12935-024-03453-8.pdf
Reference43 articles.
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2. Biagioni A, Skalamera I, Peri S, et al. Update on gastric cancer treatments and gene therapies. Cancer Metastasis Rev. 2019;38(3):537–48.
3. Tang BF, Yan RC, Wang SW, et al. Maternal embryonic leucine zipper kinase in tumor cells and tumor microenvironment: an emerging player and promising therapeutic opportunity. Cancer Lett. 2023;560: 216126.
4. Beullens M, Vancauwenbergh S, Morrice N, et al. Substrate specifificity and activity regulation of protein kinase MELK. J Biol Chem. 2005;280(48):40003–11.
5. Badouel C, Chartrain I, Blot J, et al. Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit. Exp Cell Res. 2010;316(13):2166–73.
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