Abstract
AbstractMucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Reference68 articles.
1. Porrello A, Cardelli P, Spugnini E. Oncology of companion animals as a model for humans. An overview of tumor histotypes. J Exp Clin Cancer Res. 2006;25(1):97–105.
2. Vail DM, Macewen EG. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest. 2000;18(8):781–92.
3. Owen L. A comparative study of canine and human breast cancer. Invest Cell Pathol. 1979;2(4):257.
4. Marchesi M, Manuali E, Pacifico E, Ferri C, Romagnoli M, Mangili V, et al. Cancer antigen 15/3: possible diagnostic use in veterinary clinical oncology. Preliminary study. Vet Res Commun. 2010;34(1):103–6.
5. Fürdös I, Fazekas J, Singer J, Jensen-Jarolim E. Translating clinical trials from human to veterinary oncology and back. J Transl Med. 2015;13(1):1–7.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献