Author:
López-Calleja Ana Isabel,Gavín Patricia,Lezcano Ma Antonia,Vitoria Ma Asunción,Iglesias Ma José,Guimbao Joaquín,Lázaro Ma Ángeles,Rastogi Nalin,Revillo Ma José,Martín Carlos,Samper Sofia
Abstract
Abstract
Background
A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004.
Methods
The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed.
Results
The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB.
Conclusion
The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine
Reference39 articles.
1. World Health Organization: Global tuberculosis control: surveillance, planning, financing. WHO report 2007. (WHO/HTM/TB/2007.376). 2007, Geneva, World Health Organization
2. Mathema B, Kurepina NE, Bifani PJ, Kreiswirth BN: Molecular Epidemiology of Tuberculosis: Current Insights. Clin Microbiol Rev. 2006, 19: 658-685. 10.1128/CMR.00061-05.
3. Bifani PJ, Plikaytis BB, Kapur V, Stockbauer K, Pan X, Lutfey ML, Moghazeh SL, Eisner W, Daniel TM, Kaplan MH, Crawford JT, Musser JM, Kreiswirth BN: Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family. JAMA. 1996, 275: 452-457. 10.1001/jama.275.6.452.
4. Bifani PJ, Mathema B, Liu Z, Moghazeh SL, Shopsin B, Tempalski B, Driscol J, Frothingham R, Musser JM, Alcabes P, Kreiswirth BN: Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology. JAMA. 1999, 282: 2321-2327. 10.1001/jama.282.24.2321.
5. Caminero JA, Pena MJ, Campos-Herrero MI, Rodríguez JC, García I, Cabrera P, Lafoz C, Samper S, Takiff H, Afonso O, Pavón JM, Torres MJ, van Soolingen D, Enarson DA, Martin C: Epidemiological evidence of the spread of a Mycobacterium tuberculosis strain of the Beijing genotype on Gran Canaria Island. Am J Respir Crit Care Med. 2001, 164: 1165-1170.
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献