Author:
Tabatabaizadeh Mashallah,Hasibi Taheri Sara,Eydi Mohammad,Shayestehpour Mohammad
Abstract
Abstract
Background
Thyroid papillary carcinoma is one of the most common endocrine tumors, and it accounts for 85% of thyroid tumors. Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome is a rare disease. In this case report, we discuss a very rare case of coexistence of papillary thyroid carcinoma and Cushing's syndrome with an adrenal origin.
Case presentation
The patient was a 33-year-old Iranian/Persian woman with a history of papillary thyroid carcinoma treated with iodine 131 three years ago. She presented with weight gain, amenorrhea, and mood disorders in the last six months. She was diagnosed with an ACTH-independent Cushing's syndrome due to benign adrenal adenoma and underwent laparoscopic adrenalectomy surgery. The symptoms of the syndrome were disappeared after the surgery.
Conclusions
ACTH-independent Cushing's syndrome due to adrenal tumor and papillary thyroid cancer occurs sporadically. The co-occurrence of two endocrine tumors with different origins is rare. It is recommended that the occurrence of other endocrine neoplasms be considered when an endocrine tumor is diagnosed.
Publisher
Springer Science and Business Media LLC
Reference5 articles.
1. Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J. Harrison’s principles of internal medicine. 20th ed. New York: McGraw Hill Education; 2018.
2. Mazeh H, Orlev A, Mizrahi I, Gross DJ, Freund HR. Concurrent medullary, papillary, and follicular thyroid carcinomas and simultaneous Cushing’s syndrome. Eur Thyroid J. 2015;4(1):65–8.
3. Karakose M, Hasdemir O, Cakal E, Delibasi T. A rare coexistence of non-functional adrenocortical carcinoma and multicentric papillary thyroid microcarcinoma: a case report. J Med Case Rep. 2013;7:200.
4. Tung S-C, Wang P-W, Huang T-L, Yang JW, Chen W-J. Carney complex with primary pigmented nodular adrenocortical disease and bilateral papillary thyroid carcinoma occurring 11 years apart: a case report. Endocrinologist. 2005;15(4):243–7.
5. Esteghamati AR, Eshtiaghi R, Yousefizadeh AA, Nakhjavani M. Diagnosis and management of 253 cases with Cushing’s syndrome in Imam Khomeini Hospital. Tehran Univ Med J. 2007;65(7):77–82.