Abstract
Abstract
Background
The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role.
Case presentation
We report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion.
Conclusions
To our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors.
Publisher
Springer Science and Business Media LLC
Reference15 articles.
1. Cummings AL, Kaprealian TB, Sarantopoulos GP, Mendenhall MA, Goldman JW. An abscopal effect in a case of neuroendocrine atypical carcinoid lung cancer. Appl Radiat Oncol. 2017;6(3):38–9.
2. Pelosi G, Sonzogni A, Harari S, et al. Classification of pulmonary neuroendocrine tumors: new insights. Transl Lung Cancer Res. 2017;6(5):513–29.
3. Herde RF, Kokeny KE, Reddy CB, et al. Primary pulmonary carcinoid tumor: a long-term single institution experience. Am J Clin Oncol. 2018;41(1):24–9.
4. Grass GD, Krishna N, Kim S. The immune mechanisms of abscopal effect in radiation therapy. Curr Probl Cancer. 2016;40(1):10–24.
5. Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev. 2015;41(6):503–10.
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