Author:
Al Mulla Liqa,Abdelhadi Maha,Al Muhanna Afnan,Elsharkawy Tarek,Al Nemer Areej
Abstract
Abstract
Background
Adenomyoepithelioma of the breast is an uncommon subtype of breast neoplasm that occurs in adults over a wide age range but most commonly in middle-aged and older adults. It usually presents as a solitary palpable mass or is detected on breast radiographic images. Histologically, it is a biphasic tumor with proliferation of both the epithelial and myoepithelial components of the glands, with variable types of tissue metaplasia.
Case presentation
A 64-year-old Saudi woman who underwent regular breast screening (mammogram) presented to our hospital following radiographic detection of a suspicious grouped microcalcification in the upper outer quadrant of her right breast on the mammogram. A wide local excision of the right breast lump was performed. Following histopathological examination of the breast lump, the final diagnosis was breast adenomyoepithelioma with mucoepidermoid/divergent differentiation, with no evidence of malignancy. About two years after the operation, a clinical follow-up conducted outside our hospital showed the development of ductal carcinoma in situ in the same breast.
Conclusion
Although the prognosis and the plan of treatment remains the same, our case highlights the complexities in making an accurate diagnosis between the various types of metaplasia within adenomyoepithelioma on one hand and the presence of mucoepidermoid differentiation in adenomyoepithelioma on the other.
Publisher
Springer Science and Business Media LLC
Reference19 articles.
1. Hamperl H. The myothelia (myoepithelial cells): normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol. 1970;53:161–220.
2. Hoon Tan P, Ellis I, Allison K, Borgi E, Fox SB, Lakhani S et al. World Health Organization classification of tumors of breast: adenomyoepithelioma. International Agency for Research on Cancer (IARC). 5th Edition; volume 2. 2019
3. Tavassoli FA. Myoepithelial lesions of the breast: myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 1991;15(6):554–68.
4. Ito R, Ota D, Ando S, Mori M, Fukuuchi A. A case of adenomyoepithelioma with myoepithelial carcinoma of the breast. Clin Case Rep. 2019;7(5):930–4.
5. Hayes MM. Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation. J Clin Pathol. 2011;64(6):477–84.
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