Author:
Yamasaki Arina,Bito Daisuke,Eto Erina,Matsumoto Keiichiro,Nakamura Megumi,Miyazaki Junji,Matsumoto Kenichi,Masuda Masanori,Mori Daisuke,Yoshimura Toru
Abstract
Abstract
Background
Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney.
Case presentation
We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly.
Conclusion
The patient’s urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased.
Publisher
Springer Science and Business Media LLC
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