Applying results from clinical trials: tranexamic acid in trauma patients

Author:

Roberts Ian,Prieto-Merino David

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Reference24 articles.

1. Okamoto S, Okamoto U: Amino-methyl-cyclohexane-carboxylic acid: AMCHA: a new potent inhibitor of fibrinolysis. Keio J Med 1962, 11: 105-115. 10.2302/kjm.11.105

2. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010,376(9734):23-32. Epub 2010/06/18 10.1016/S0140-6736(10)60835-5

3. Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T: The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011,377(9771):1096-1101. 101 e1-2. Epub 2011/03/29 10.1016/S0140-6736(11)60317-6

4. Gruen R, Jacobs I, Reade M: Tranexamic acid and trauma. Med J Aust 2014,200(5):255. 10.5694/mja13.00023

5. Pusateri A, Weiskopf R, Bebarta V, Butler F, Cestero RF, Chaudry IH, Deal V, Dorlac WC, Gerhardt RT, Given MB, Hansen DR, Hoots WK, Klein HG, Macdonald VW, Mattox KL, Michael RA, Mogford J, Montcalm-Smith EA, Niemeyer DM, Prusaczyk WK, Rappold JF, Rassmussen T, Rentas F, Ross J, Thompson C, Tucker LD: Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock 2013, 39: 121-126. 10.1097/SHK.0b013e318280409a

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