Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response-Reference-Cited by-同舟云学术

Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Published:2024-02-09 Issue:1 Volume:25 Page:
ISSN:1465-993X
Container-title:Respiratory Research
language:en
Short-container-title:Respir Res

Author:

Sevoz-Couche Caroline,Patout Maxime,Charbit Beny,Similowski Thomas,Straus Christian

Abstract

AbstractAfter a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.Clinical Trials Identifier NCT01243697

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s12931-023-02625-w.pdf

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