The Dictyostelium discoideum homologue of Twinkle, Twm1, is a mitochondrial DNA helicase, an active primase and promotes mitochondrial DNA replication
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology
Link
http://link.springer.com/content/pdf/10.1186/s12867-018-0114-7.pdf
Reference64 articles.
1. Spelbrink JN, Li F-Y, Tiranti V, Nikali K, Yuan Q-P, et al. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet. 2001;28(3):223–31.
2. Kaguni LS, Oliveira MT. Structure, function and evolution of the animal mitochondrial replicative DNA helicase. Crit Rev Biochem Mol Biol. 2015;51:1–12.
3. Farge G, Holmlund T, Khvorostova J, Rofougaran R, Hofer A, Falkenberg M. The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities. Nucleic Acids Res. 2008;36(2):393–403.
4. Fernández-Millán P, Lázaro M, Cansız-Arda Ş, Gerhold JM, Rajala N, et al. The hexameric structure of the human mitochondrial replicative helicase Twinkle. Nucleic Acids Res. 2015;43(8):4284–95.
5. Davey MJ, O’Donnell M. Replicative helicase loaders: ring breakers and ring makers. Curr Biol. 2003;13(15):R594–6.
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