When to keep it simple – adaptive designs are not always useful
Author:
Funder
Medical Research Council
Cancer Research UK
Publisher
Springer Science and Business Media LLC
Subject
General Medicine
Link
http://link.springer.com/content/pdf/10.1186/s12916-019-1391-9.pdf
Reference20 articles.
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3. Thorlund K, Haggstrom J, Park JJ, Mills EJ. Key design considerations for adaptive clinical trials: a primer for clinicians. BMJ. 2018;360:k698.
4. Hey SP, Kimmelman J. Are outcome-adaptive allocation trials ethical? Clin Trials. 2015;12(2):102–6.
5. Legocki LJ, Meurer WJ, Frederiksen S, Lewis RJ, Durkalski VL, Berry DA, et al. Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis. BMC Med Ethics. 2015;16:27.
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