Author:
Yang Xiaorong,Zhao Shaohua,Wang Shaohua,Cao Xuelei,Xu Yue,Yan Meichen,Pang Mingmin,Yi Fan,Wang Hao
Abstract
Abstract
Background
The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various indicators of systemic inflammation and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia in the UK Biobank cohort.
Methods
After excluding ineligible participants, a total of 478,524 eligible individuals (46.75% male, aged 40–69 years) were enrolled in the study to assess the association between systemic inflammatory indicators and each type of arrhythmia.
Results
After covariates were fully adjusted, CRP levels were found to have an essentially linear positive correlation with the risk of various arrhythmias; neutrophil count, monocyte count, and NLR showed a non-linear positive correlation; and lymphocyte count, SII, PLR, and LMR showed a U-shaped association. VA showed the strongest association with systemic inflammation indicators, and it was followed sequentially by AF and bradyarrhythmia.
Conclusions
Multiple systemic inflammatory indicators showed strong associations with the onset of AF, VA, and bradyarrhythmia, of which the latter two have been rarely studied. Active systemic inflammation management might have favorable effects in reducing the arrhythmia burden and further randomized controlled studies are needed.
Funder
National Natural Science Foundation of China
Taishan Scholars Program of Shandong Province
Clinical Research Center of Shandong University
National Key R&D Program of China
Publisher
Springer Science and Business Media LLC
Cited by
23 articles.
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