Author:
Yu Ke,Chen Xiao-Feng,Guo Jing,Wang Sen,Huang Xiao-Ting,Guo Yan,Dong Shan-Shan,Yang Tie-Lin
Abstract
Abstract
Background
Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain.
Methods
We performed two-sample bidirectional Mendelian randomization (MR) analyses to explore the causal associations between IDPs and stroke. Summary data of 587 brain IDPs (up to 33,224 individuals) from the UK Biobank and five stroke types (sample size range from 301,663 to 446,696, case number range from 5,386 to 40,585) from the MEGASTROKE consortium were used.
Results
Forward MR indicated 14 IDPs belong to projection fibers or association fibers were associated with stroke. For example, higher genetically determined mean diffusivity (MD) in the right external capsule was causally associated with an increased risk of small vessel stroke (IVW OR = 2.76, 95% CI 2.07 to 3.68, P = 5.87 × 10−12). Reverse MR indicated that genetically determined higher risk of any ischemic stroke was associated with increased isotropic or free water volume fraction (ISOVF) in body of corpus callosum (IVW β = 0.23, 95% CI 0.14 to 0.33, P = 3.22 × 10−7). This IDP is a commissural fiber and it is not included in the IDPs identified by forward MR.
Conclusions
We identified 14 IDPs with statistically significant evidence of causal effects on stroke or stroke subtypes. We also identified potential causal effects of stroke on one IDP of commissural fiber. These findings might guide further work toward identifying preventative strategies at the brain imaging levels.
Funder
National Natural Science Foundation of China
Science Fund for Distinguished Young Scholars of Shaanxi Province
Innovation Capability Support Program of Shaanxi Province
Postdoctoral Research Foundation of China
Key Research and Development Project of Shaanxi Province
Fundamental Research Funds for the Central Universities
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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