Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process-Reference-Cited by-同舟云学术

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Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process

Published:2014-03-05 Issue:1 Volume:13 Page:
ISSN:1475-2859
Container-title:Microbial Cell Factories
language:en
Short-container-title:Microb Cell Fact

Author:

Fu Zhibiao,Verderame Thomas D,Leighton Julie M,Sampey Brante P,Appelbaum Edward R,Patel Pramatesh S,Aon Juan C

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://link.springer.com/content/pdf/10.1186/1475-2859-13-32.pdf

Reference35 articles.

1. Ferrer-Miralles N, Domingo-Espin J, Corchero JL, Vazquez E, Villaverde A: Microbial factories for recombinant pharmaceuticals. Microb Cell Fact. 2009, 8: 17-24. 10.1186/1475-2859-8-17.

2. Holmes WJ, Darby RAJ, Wilks MDB, Smith R, Bill RM: Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime. Microb Cell Fact. 2009, 8: 35-48. 10.1186/1475-2859-8-35.

3. Siurkus J, Panula-Perala J, Horn U, Kraft M, Rimseliene R, Neubauer P: Novel approach of high cell density recombinant bioprocess development: optimization and scale-up from microlitre to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures. Microb Cell Fact. 2010, 9: 35-51. 10.1186/1475-2859-9-35.

4. Amanullah A, BuckLand BC, Nienow AW: Mixing in the fermentation and cell culture industries. Handbook of Industrial Mixing: Science and Practice. Edited by: Paul EL, Atiemo-Obeng VA, Kresta SM. 2003, 1071-1170. New York: John Wiley & Sons

5. Xu B, Jahic M, Blomsten G, Enfors SO: Glucose overflow metabolism and mixed-acid fermentation in aerobic large-scale fed-batch processes with Escherichia coli. Appl Microbiol Biotechnol. 1999, 51: 564-571. 10.1007/s002530051433.

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