Author:
Galao Rui P,Scheller Nicoletta,Alves-Rodrigues Isabel,Breinig Tanja,Meyerhans Andreas,Díez Juana
Abstract
Abstract
The yeast Saccharomyces cerevisiae is a well-established model system for understanding fundamental cellular processes relevant to higher eukaryotic organisms. Less known is its value for virus research, an area in which Saccharomyces cerevisiae has proven to be very fruitful as well. The present review will discuss the main achievements of yeast-based studies in basic and applied virus research. These include the analysis of the function of individual proteins from important pathogenic viruses, the elucidation of key processes in viral replication through the development of systems that allow the replication of higher eukayotic viruses in yeast, and the use of yeast in antiviral drug development and vaccine production.
Publisher
Springer Science and Business Media LLC
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Reference89 articles.
1. Parsons AB, Geyer R, Hughes TR, Boone C: Yeast genomics and proteomics in drug discovery and target validation. Prog Cell Cycle Res. 2003, 5: 159-166.
2. Foury F: Human genetic diseases: a cross-talk between man and yeast. Gene. 1997, 195 (1): 1-10. 10.1016/S0378-1119(97)00140-6.
3. Coller J, Parker R: Eukaryotic mRNA decapping. Annu Rev Biochem. 2004, 73: 861-890. 10.1146/annurev.biochem.73.011303.074032.
4. Schwartz DC: Interaction of mRNA translation adn mRNA degradation in Saccharomyces cerevisiae. Translation control of gene expression. Edited by: Sonenber NHJWBMMB. 2000, Cold Spring Harbor, New York , Cold Spring Harbor Laboratory Press, 807-825.
5. Tsukuda T, Fleming AB, Nickoloff JA, Osley MA: Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature. 2005, 438 (7066): 379-383. 10.1038/nature04148.
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