PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response

Author:

Saulle Ernestina,Petronelli Alessia,Pelosi Elvira,Coppotelli Elena,Pasquini Luca,Ilari Ramona,Lo-Coco Francesco,Testa Ugo

Funder

Programma Oncotecnologico, Italy

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Biology,Hematology

Reference35 articles.

1. Soufi A, Jayaraman PS. PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate. Biochem J. 2008;412:399–413.

2. Hallaq H, Pinter E, Enciso J, et al. A null mutation of HHEX results in abnormal cardiac development, defective vasculogenesis and elevated VEGFA levels. Development. 2004;131:5197–204.

3. Martinez Barbera JP, Clements M, Thomas P, et al. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development. 2000;127:2433–45.

4. Thomas PQ, Brown A, Beddington RS. Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development. 1998;125:85–94.

5. Bedford FK, Ashworth A, Enver T, Wiedemann LM. HEX: a novel homeobox gene expressed during hematopoiesis and conserved between mouse and human. Nucleic Acids Res. 1993;21:1245–9.

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