Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

Author:

López-Iglesias Ana-Alicia,Herrero Ana B.,Chesi Marta,San-Segundo Laura,González-Méndez Lorena,Hernández-García Susana,Misiewicz-Krzeminska Irena,Quwaider Dalia,Martín-Sánchez Montserrat,Primo Daniel,Paíno Teresa,Bergsagel P. Leif,Mehrling Thomas,González-Díaz Marcos,San-Miguel Jesús F.,Mateos María-Victoria,Gutiérrez Norma C.,Garayoa Mercedes,Ocio Enrique M.

Funder

ISCIII-FIS

Spanish RTICC

Fundación Científica Asociación Española Contra el Cáncer

Regional Council of Castilla y León

Fundación Científica Asociación Española Contra el Cáncer (ES)

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Biology,Hematology

Reference47 articles.

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2. Majithia N, Vincent Rajkumar S, Lacy MQ, Buadi FK, Dispenzieri A, Gertz MA, et al. Outcomes of primary refractory multiple myeloma and the impact of novel therapies. Am J Hematol. 2015;90:981–5.

3. BERGSAGEL DE, SPRAGUE CC, AUSTIN C, GRIFFITH KM. Evaluation of new chemotherapeutic agents in the treatment of multiple myeloma. IV. L-Phenylalanine mustard (NSC-8806). Cancer Chemother Rep. 1962;21:87–99.

4. Chauhan D, Ray A, Viktorsson K, Spira J, Paba-Prada C, Munshi N, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res Off J Am Assoc Cancer Res. 2013;19:3019–31.

5. Mateos M-V, Oriol A, Rosiñol L, de Arriba F, Puig N, Martín J, et al. Bendamustine, bortezomib and prednisone for the treatment of patients with newly diagnosed multiple myeloma: results of a prospective phase 2 Spanish/PETHEMA trial. Haematologica. 2015;100:1096–102.

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