MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies-Reference-Cited by-同舟云学术

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

Published:2021-08-09 Issue:1 Volume:14 Page:
ISSN:1756-8722
Container-title:Journal of Hematology & Oncology
language:en
Short-container-title:J Hematol Oncol

Author:

Ahmadi Seyed Esmaeil,Rahimi Samira,Zarandi Bahman,Chegeni Rouzbeh,Safa Majid^ORCID

Abstract

AbstractMYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Biology,Hematology

Link

https://link.springer.com/content/pdf/10.1186/s13045-021-01111-4.pdf

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