Author:
Zhao Juanjuan,Ren Quan,Liu Xinyuan,Guo Xiangqian,Song Yongping
Abstract
AbstractSeveral bispecific antibodies (bsAbs) targeting BCMA, GPRC5D, and FcRH5 are in clinical trials for heavily pretreated multiple myeloma (MM) patients. Teclistamab was approved for relapsed/refractory MM therapy in 2022, while elranatamab, linvoseltamab, F182112, talquetamab, and cevostamab are currently undergoing clinical trials. This study summarizes several latest reports on bsAbs for the treatment of MM from the ASCO 2023 Annual Meeting.
Funder
China Postdoctoral Science Foundation
The First Affiliated Hospital of Zhengzhou University
The Major Project of Henan Medical Science and Technology Research Plan
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Biology,Hematology
Reference13 articles.
1. Moreau P, Garfall AL, Bhutani M, Oriol A, Nooka AK, Martin TG, Rosiñol L, Mateos M-V, Bahlis NJ, Popat R, Besemer B, Martinez-Lopez J, Krishnan AY, Delforge M, Trancucci D, Verona R, Stephenson T, Chastain K, Sidana S. Long-term follow-up from MajesTEC-1 of teclistamab, a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM). J Clin Oncol. 2023;41(16_suppl):8011–8011.
2. Shekarkhand T, Patel D, Tan CRC, Hultcrantz M, Lesokhin AM, Mailankody S, Hassoun H, Shah UA, Korde N, Maclachlan K, Landau HJ, Scordo M, Chung DJ, Shah GL, Lahoud OB, Giralt S, Usmani SZ. Evaluating the efficacy of commercial teclistamab in relapsed refractory multiple myeloma patients with prior exposure to anti-BCMA therapies. J Clin Oncol. 2023;41(16_suppl):8049–8049.
3. Hungria VT, Bhutani D, Landgren O, Vieyra D, Guo Y, Verona R, Miao X, Qi M, Watkins L, Shah P, Chastain K, Qi M, Quach H. MajesTEC-9: a randomized phase 3 study of teclistamab versus pomalidomide, bortezomib, and dexamethasone or carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma. J Clin Oncol. 2023;41(16_suppl):8067–8067.
4. Tomasson MH, Arnulf B, Bahlis NJ, Prince HM, Niesvizky R, Rodríguez-Otero P, Martinez-Lopez J, Koehne G, Jethava Y, Gabayan AE, Stevens DA, Nooka AK, Raje NS, Iida S, Leip E, Conte U, Czibere AG, Viqueira A, Lesokhin AM. Elranatamab, a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, for patients (pts) with relapsed/refractory multiple myeloma (RRMM): extended follow up and biweekly administration from the MagnetisMM-3 study. J Clin Oncol. 2023;41(16_suppl):8039–8039.
5. Yeh S-P, Huang JSY, Byun JM, DiRienzo C, Viqueira A. MagnetisMM-6: an open-label, multicenter, randomized phase 3 study of elranatamab + daratumumab + lenalidomide (EDR) versus daratumumab + lenalidomide + dexamethasone (DRd) in transplant ineligible (TI) patients with newly diagnosed multiple myeloma (NDMM). J Clin Oncol. 2023;41(16_suppl):TPS065-TPS8065.
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