Bispecific antibodies targeting BCMA, GPRC5D, and FcRH5 for multiple myeloma therapy: latest updates from ASCO 2023 Annual Meeting

Author:

Zhao Juanjuan,Ren Quan,Liu Xinyuan,Guo Xiangqian,Song Yongping

Abstract

AbstractSeveral bispecific antibodies (bsAbs) targeting BCMA, GPRC5D, and FcRH5 are in clinical trials for heavily pretreated multiple myeloma (MM) patients. Teclistamab was approved for relapsed/refractory MM therapy in 2022, while elranatamab, linvoseltamab, F182112, talquetamab, and cevostamab are currently undergoing clinical trials. This study summarizes several latest reports on bsAbs for the treatment of MM from the ASCO 2023 Annual Meeting.

Funder

China Postdoctoral Science Foundation

The First Affiliated Hospital of Zhengzhou University

The Major Project of Henan Medical Science and Technology Research Plan

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Biology,Hematology

Reference13 articles.

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