Abstract
AbstractPrimary liver cancer (PLC) is a common malignancy with high morbidity and mortality. Poor prognosis and easy recurrence on PLC patients calls for optimizations of the current conventional treatments and the exploration of novel therapeutic strategies. For most malignancies, including PLC, immune cells play crucial roles in regulating tumor microenvironments and specifically recognizing tumor cells. Therefore, cellular based immunotherapy has its instinctive advantages in PLC therapy as a novel therapeutic strategy. From the active and passive immune perspectives, we introduced the cellular based immunotherapies for PLC in this review, covering both the lymphoid and myeloid cells. Then we briefly review the combined cellular immunotherapeutic approaches and the existing obstacles for PLC treatment.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shanghai
Yangfan Project of Shanghai Science and Technology Commission
Health System Innovation Project of Shanghai Putuo Science and Technology Commission
Chinese Foundation for Hepatitis Prevention and Control
Publisher
Springer Science and Business Media LLC
Cited by
16 articles.
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