Abstract
AbstractOver the last decade, accumulating evidence has suggested that tumor-associated macrophages (TAMs) play a significant role in the tumor development. This commentary wishes to highlight the findings by You, et al. that M1-like TAMs could cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma (OSCC) via the IL6/Stat3/THBS1 feedback loop. These unprecedented findings identified M1-like TAMs-regulated processes as potentially tumor-promotion in the context of OSCC immunomicroenvironment.
Funder
National Natural Science Foundation of China
Open Project of Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
Xinjiang Postgraduate Scientific Research Innovation Project
Publisher
Springer Science and Business Media LLC
Reference17 articles.
1. Lazarov T, Juarez-Carreño S, Cox N, Geissmann F. Physiology and diseases of tissue-resident macrophages. Nature. 2023;618(7966):698–707.
2. Li CX, Gong ZC, Zheng NB. Progress in the regulatory effects of tumor-derived exosomes on macrophage polarization. Chin J Microbiol Immunol. 2023;43(01):76–83.
3. Christofides A, Strauss L, Yeo A, Cao C, Charest A, Boussiotis VA. The complex role of tumor-infiltrating macrophages. Nat Immunol. 2022;23(8):1148–56.
4. Li M, Yang Y, Xiong L, Jiang P, Wang J, Li C. Metabolism, metabolites, and macrophages in cancer. J Hematol Oncol. 2023;16(1):80.
5. Zong Z, Zou J, Mao R, Ma C, Li N, Wang J, et al. M1 macrophages induce PD-L1 expression in Hepatocellular Carcinoma cells through IL-1β signaling. Front Immunol. 2019;10:1643.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献