Abstract
AbstractA novel electrochemical sensor was developed for the detection of Epinephrine (EP) utilizing Azure A (AzA), a phenothiazine dye, and citrate-capped silver nanoparticles. The interaction between Azure A and silver nanoparticles facilitated the formation of AzA/silver nanoclusters through a self-assembled approach. The morphological analysis of AzA/silver nanoclusters was conducted using field-emission scanning electron microscopy (FESEM). The nanoclusters were then immobilized on a graphite electrode via a simple drop-casting method, resulting in a modified electrode. The electrochemical properties of the modified electrode were investigated using cyclic voltammetry and linear sweep voltammetry techniques. The modified electrode exhibited enhanced electrocatalytic oxidation of EP at a lower oxidation potential of 0.27 V. The electrochemical analysis demonstrated that the modified electrode functioned as an amperometric sensor, enabling the detection of EP within a concentration range of 4.6 × 10–7 to 3.6 × 10–3 M, with a correlation coefficient of 0.9950 and a detection limit of 2.2 × 10–7 M (S/N = 3). The modified electrode exhibited excellent selectivity, sensitivity, and a remarkably low detection limit, making it highly suitable for EP determination. Its ease of preparation further adds to the practicality and potential applications of this electrode.
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Biomaterials