Abstract
Abstract
Background
Scorpion venom is a very complicated mixture of various peptides/proteins which could induce toxicological and pharmacological responses. This investigation was conducted to evaluate the possible pharmacological properties (analgesic, antipyretic, and antiinflammatory effects) of the Egyptian scorpion venom Androctonus amoreuxi in mice and rats injected intraperitoneally with 1/10 and 1/5 LD50 (0.11 and 0.22 mg/kg for mice; 0.385 and 0.77 mg/kg for rats, respectively).
Results
The peripheral and central analgesic effect of A. amoreuxi venom was determined using the tests of mice-abdominal writhing and tail immersion of rats, respectively. The antipyretic and antiinflammatory activities were examined using the pyrexia rats model induced by Brewer’s yeast and the paw mice edema induced by carrageenan, respectively. The venom of A. amoreuxi produced significant (p < 0.05) peripheral and central analgesic activity in both animal models. Also, treatment with the scorpion venom showed significant (p < 0.05) dose-independent reduction in pyrexia of rats. More importantly, the venom significantly inhibited mice paw edema induced by carrageenan.
Conclusion
Accordingly, the present results showed that the venom of this scorpion possesses remarkable pharmacological properties (analgesic, antipyretic, and antiinflammatory activities) on animal models, and might be contain certain peptides responsible for the reported activities.
Publisher
Springer Science and Business Media LLC
Reference51 articles.
1. Abdel-Rahman, M. A., Quintero-Hernández, V., & Possani, L. D. (2013). Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae). Toxicon, 74, 193–207.
2. Abdel-Rahman, M. A., Harrison, P. L., & Strong, P. N. (2015). Snapshots of scorpion venomics. Journal of Arid Environments, 112, 170–176.
3. Abramson, S. B., & Weissman, G. (1989). The mechanism of action of nonsteroidal anti-inflammatory drugs. Arthritis and Rheumatism, 32, 1–9.
4. Ahmadi, M., Zare Mirakabadi, A., Hashemlou, M., & Hejazi, M. (2009). Study on anti-inflammatory effect of scorpion (Mesobuthus eupeus) venom in adjuvant-induced arthritis in rats. Archives of Razi Institute, 64, 51–56.
5. Almaaytah, A., Zhou, M., Wang, L., Chen, T., Walker, B., & Shaw, C. (2012). Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. Peptides, 35(2), 291–299.
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