Abstract
Abstract
Background
Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound using data from a large publically available database.
Results
The pedigree used for this study included 5110 pure-bred Irish Wolfhounds, including 332 dogs diagnosed with OSA and 360 control dogs; dogs were considered controls if they lived over 10 years of age and were not reported to have developed OSA. The estimated heritability of OSA in the Irish Wolfhound was 0.65.
Conclusion
The results of this study indicate that OSA in the Irish Wolfhound is highly heritable, and support the need for future research investigating associated genetic mutations.
Funder
foundation for the national institutes of health
american kennel club canine health foundation
Publisher
Springer Science and Business Media LLC
Reference31 articles.
1. Moore AS, Dernell WS, Ogilvie GK, Kristal O, Elmslie R, Kitchell B, et al. Doxorubicin and BAY 12-9566 for the treatment of osteosarcoma in dogs: a randomized double-blinded, placebo-controlled study. J Vet Intern Med. 2007;21:783–90. https://doi.org/10.1892/0891-6640(2007)21[783:dabftt]2.0.co;2.
2. Frimberger AR, Chan CM, Moore AS. Canine osteosarcoma treated by post-amputation sequential accelerated doxorubicin and carboplatin chemotherapy: 38 cases. J Am Anim Hosp Assoc. 2016;52:149–56. https://doi.org/10.5326/JAAHA-MS-6315.
3. Grüntzig K, Graf R, Boo G, Guscetti F, Hassig M, Axhausen KW, et al. Swiss canine cancer registry 1955-2008: occurrence of the most common tumour diagnoses and influence of age, breed, body size, sex and neutering status on tumour development. J Comp Pathol. 2016;155:156–70. https://doi.org/10.1016/j.jcpa.2016.05.011.
4. Egenvall A, Nødtvedt A, von Euler H. Bone tumors in a population of 400 000 insured Swedish dogs up to 10y of age: incidence and survival. Can J Vet Res. 2007;71:292–9.
5. Bernardi G. Longevity and morbidity in the Irish wolfhound in the United States – 1966 to 1986. https://www.iwclubofamerica.org/longevityBernardi. Accessed 19 May 2021.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献