Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China
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Published:2023-04-18
Issue:1
Volume:17
Page:
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ISSN:1753-2000
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Container-title:Child and Adolescent Psychiatry and Mental Health
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language:en
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Short-container-title:Child Adolesc Psychiatry Ment Health
Author:
Zhou Yesheng,Tang Kailing,Lu Hongyan,Chen Hongli,Xie Haomin,Li Zeyu,Huang Jinghua,Fang Ningye,Chen Siya,Wang Hong,He Qin,Chen Huanhuan,Liu Xiu,Lan Guanghua,Zhu Qiuying,Chen Yi,Zhang Xiangjun,Ruan Yuhua,Liang Shujia
Abstract
Abstract
Background
Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes.
Methods
This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants’ HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure.
Results
The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure.
Conclusions
Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes.
Funder
Ministry of Science and Technology of China
Guangxi Natural Science Foundation Project
Guangxi Key Laboratory of AIDS Prevention Control and Translation
Guangxi Bagui Honor Scholarship
Guangxi Medical and health key discipline construction project
National Natural Science Foundation of China
Chinese State Key Laboratory of Infectious Disease Prevention and Control
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pediatrics, Perinatology and Child Health
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