Author:
Al-Sabah Reem,Al-Taiar Abdullah,Shaban Lemia,Albatineh Ahmed N.,Sharaf Alddin Reem,Durgampudi Praveen K.
Abstract
Abstract
Background
This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and depression symptoms among adolescents in Kuwait, a country with a high prevalence of vitamin D deficiency.
Methods
A school based cross-sectional study was conducted on randomly selected 704 adolescents in middle schools. Data on depression symptoms were collected using the Children’s Depression Inventory (CDI). Data on covariates were collected from the parents by self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were analyzed in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem mass spectrometry.
Results
Of 704 adolescents, 94 (13.35%; 95%CI:10.35–17.06%) had depression symptom (a score of 19 or more on the CDI). There was no significant difference in the median CDI score between different vitamin D status (p = 0.366). There was also no significant correlation between serum 25(OH)D concentration and CDI score (Spearman’s rank correlation = 0.01; p = 0.825).There was no significant association between 25(OH)D and depression symptoms whether 25(OH)D was fitted as a continuous variable (crude odds ratio (OR) 0 .99 [95%CI: 0.98, 1.01], p = 0.458 and adjusted OR 1.01 [95%CI: 0.99, 1.02], p = 0.233), categorical variable as per acceptable cut-of points (crude analysis p = 0.376 and adjusted analysis p = 0.736), or categorical variable as quartiles (crude analysis p = 0.760 and adjusted analysis p = 0.549).
Conclusion
Vitamin D status does not seem to be associated with depression symptoms among adolescents in our setting. Nevertheless, it is important to have sufficient vitamin D levels during adolescence for several other health benefits.
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pediatrics, Perinatology and Child Health
Reference82 articles.
1. GBD. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet (London, England). 2016;10053:1545–602.
2. WHO. Depression: Key fact: World Health Organization 2021 https://www.who.int/news-room/fact-sheets/detail/depression#:~:text=Depression%20is%20a%20common%20mental,affected%20by%20depression%20than%20men.
3. Kirsch I. Review: benefits of antidepressants over placebo limited except in very severe depression. Evid Based Ment Health. 2010;13(2):49.
4. Sanchez-Villegas A, Martínez-González MA. Diet, a new target to prevent depression? BMC Med. 2013;11:3.
5. Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, et al. A randomised controlled trial of dietary improvement for adults with major depression (the “SMILES” trial). BMC Med. 2017;15(1):23.
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