SARS-CoV-2 and interferon blockade-Reference-Cited by-同舟云学术

SARS-CoV-2 and interferon blockade

Published:2020-11-09 Issue:1 Volume:26 Page:
ISSN:1076-1551
Container-title:Molecular Medicine
language:en
Short-container-title:Mol Med

Author:

Diamond Betty,Volpe Bruce T.^ORCID,VanPatten Sonya,Al Abed Yousef

Abstract

Abstract The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

Funder

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1186/s10020-020-00231-w.pdf

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